Bioanalytical Challenges Of Antibody Drug Conjugates

Bioanalysis of antibody-drug conjugates (ADCs) is essential for evaluating the safety and efficacy of this rapidly increasing class of pharmaceuticals. Here are some of the reasons that make ADC bioanalysis so complicated. ADCs are made up of cytotoxic small molecule drugs that have been chemically linked to an antibody. The antibody recognizes a tumor-associated antigen that is only expressed in a limited number of normal cells.

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